The Mycobacterium tuberculosis cytochrome bcc:aa3 cryo-EM structure and discovery of novel putative cytochrome bcc:aa3 inhibitors

• 主要作者: Mathiyazakan, Vikneswaran
• 其他作者: Kevin Pethe
• 格式: Thesis-Doctor of Philosophy
• 語言: English
• 出版: Nanyang Technological University 2023
• 主題: Science::Biological sciences::Microbiology; Science::Biological sciences::Biochemistry
• 在線閱讀: https://hdl.handle.net/10356/169902

Tuberculosis is the second leading cause of death caused by a single causative agent. The M. tuberculosis oxidative phosphorylation (OXPHOS) pathway terminal oxidases cyt-bcc:aa3 and cyt-bd were successfully targeted by Telacebec and ND-011992 respectively. The interest to understand the M. tubercul...