The Mycobacterium tuberculosis cytochrome bcc:aa3 cryo-EM structure and discovery of novel putative cytochrome bcc:aa3 inhibitors

• Main Author: Mathiyazakan, Vikneswaran
• Other Authors: Kevin Pethe
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2023
• Subjects: Science::Biological sciences::Microbiology; Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/169902
• Institution: Nanyang Technological University

Tuberculosis is the second leading cause of death caused by a single causative agent. The M. tuberculosis oxidative phosphorylation (OXPHOS) pathway terminal oxidases cyt-bcc:aa3 and cyt-bd were successfully targeted by Telacebec and ND-011992 respectively. The interest to understand the M. tubercul...