The Mycobacterium tuberculosis cytochrome bcc:aa3 cryo-EM structure and discovery of novel putative cytochrome bcc:aa3 inhibitors

• المؤلف الرئيسي: Mathiyazakan, Vikneswaran
• مؤلفون آخرون: Kevin Pethe
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2023
• الموضوعات: Science::Biological sciences::Microbiology; Science::Biological sciences::Biochemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/169902
• المؤسسة: Nanyang Technological University

Tuberculosis is the second leading cause of death caused by a single causative agent. The M. tuberculosis oxidative phosphorylation (OXPHOS) pathway terminal oxidases cyt-bcc:aa3 and cyt-bd were successfully targeted by Telacebec and ND-011992 respectively. The interest to understand the M. tubercul...