Mechano-responsive hydrogel for direct stem cell manufacturing to therapy

• Main Authors: Shou, Yufeng, Liu, Ling, Liu, Qimin, Le, Zhicheng, Lee, Khang Leng, Li, Hua, Li, Xianlei, Koh, Dion Zhanyun, Wang, Yuwen, Liu, Tong Ming, Yang, Zheng, Lim, Chwee Teck, Cheung, Christine, Tay, Andy
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Mesenchymal Stem Cell; Dynamic Mechanical Stimulation
• Online Access: https://hdl.handle.net/10356/170381
• Institution: Nanyang Technological University

Bone marrow-derived mesenchymal stem cell (MSC) is one of the most actively studied cell types due to its regenerative potential and immunomodulatory properties. Conventional cell expansion methods using 2D tissue culture plates and 2.5D microcarriers in bioreactors can generate large cell numbers,...