Heterostructural nanoadjuvant CuSe/CoSe₂ for potentiating ferroptosis and photoimmunotherapy through intratumoral blocked lactate efflux

• Main Authors: Yang, Chunzheng, Wang, Man, Chang, Mengyu, Yuan, Meng, Zhang, Wenying, Tan, Jia, Ding, Binbin, Ma, Ping'an, Lin, Jun
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2023
• Subjects: Engineering::Bioengineering; Biological Transport; Ferroptosis
• Online Access: https://hdl.handle.net/10356/170559
• Institution: Nanyang Technological University

The desirable curative effect in clinical immunotherapy has been challenging due to the immunosuppressive tumor microenvironment (TME) with high lactic acid (LA) metabolism in solid tumors. Although targeting metabolic reprogramming of tumor cells can restore the survival and function of immune cell...