Kinetic frustration by limited bond availability controls the LAT protein condensation phase transition on membranes

• Main Authors: Sun, Simou, GrandPre, Trevor, Limmer, David T., Groves, Jay T.
• Other Authors: Institute for Digital Molecular Analytics and Science (IDMxS)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Chemistry; Amino Acids; Protein-Protein Interactions
• Online Access: https://hdl.handle.net/10356/170826
• Institution: Nanyang Technological University

LAT is a membrane-linked scaffold protein that undergoes a phase transition to form a two-dimensional protein condensate on the membrane during T cell activation. Governed by tyrosine phosphorylation, LAT recruits various proteins that ultimately enable condensation through a percolation network of...