Kinetic frustration by limited bond availability controls the LAT protein condensation phase transition on membranes
LAT is a membrane-linked scaffold protein that undergoes a phase transition to form a two-dimensional protein condensate on the membrane during T cell activation. Governed by tyrosine phosphorylation, LAT recruits various proteins that ultimately enable condensation through a percolation network of...
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Main Authors: | Sun, Simou, GrandPre, Trevor, Limmer, David T., Groves, Jay T. |
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Other Authors: | Institute for Digital Molecular Analytics and Science (IDMxS) |
Format: | Article |
Language: | English |
Published: |
2023
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/170826 |
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Institution: | Nanyang Technological University |
Language: | English |
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