Early pathogenesis profiles across SARS-CoV-2 variants in K18-hACE2 mice revealed differential triggers of lung damages

• Main Authors: Aw, Zhen Qin, Mok, Chee Keng, Wong, Yi Hao, Chen, Huixin, Mak, Tze Minn, Lin, Raymond T. P., Lye, David C., Tan, Kai Sen, Chu, Justin Jang Hann
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; SARS-CoV-2; Immune Response
• Online Access: https://hdl.handle.net/10356/171052
• Institution: Nanyang Technological University

The on-going COVID-19 pandemic has given rise to SARS-CoV-2 clades and variants with differing levels of symptoms and severity. To this end, we aim to systematically elucidate the changes in the pathogenesis as SARS-CoV-2 evolved from ancestral to the recent Omicron VOC, on their mechanisms (e.g. cy...