The iHealth-T2D study: a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes-a statistical analysis plan

South Asians are at high risk of type 2 diabetes (T2D). Lifestyle modification is effective at preventing T2D amongst South Asians, but the approaches to screening and intervention are limited by high costs, poor scalability and thus low impact on T2D burden. An intensive family-based lifestyle modi...

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Main Authors:	Muilwijk, Mirthe, Loh, Marie, Mahmood, Sara, Palaniswamy, Saranya, Siddiqui, Samreen, Silva, Wnurinham, Frost, Gary S., Gage, Heather M., Jarvelin, Marjo-Riitta, Rannan-Eliya, Ravindra P., Ahmad, Sajjad, Jha, Sujeet, Kasturiratne, Anuradhani, Katulanda, Prasad, Khawaja, Khadija I., Kooner, Jaspal S., Wickremasinghe, Ananda R., van Valkengoed, Irene G. M., Chambers, John Campbell
Other Authors:	Lee Kong Chian School of Medicine (LKCMedicine)
Format:	Article
Language:	English
Published:	2023
Subjects:	Science::Medicine Type 2 Diabetes South Asian
Online Access:	https://hdl.handle.net/10356/171103
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Institution:	Nanyang Technological University
Language:	English

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spelling	sg-ntu-dr.10356-1711032023-10-15T15:38:07Z The iHealth-T2D study: a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes-a statistical analysis plan Muilwijk, Mirthe Loh, Marie Mahmood, Sara Palaniswamy, Saranya Siddiqui, Samreen Silva, Wnurinham Frost, Gary S. Gage, Heather M. Jarvelin, Marjo-Riitta Rannan-Eliya, Ravindra P. Ahmad, Sajjad Jha, Sujeet Kasturiratne, Anuradhani Katulanda, Prasad Khawaja, Khadija I. Kooner, Jaspal S. Wickremasinghe, Ananda R. van Valkengoed, Irene G. M. Chambers, John Campbell Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Type 2 Diabetes South Asian South Asians are at high risk of type 2 diabetes (T2D). Lifestyle modification is effective at preventing T2D amongst South Asians, but the approaches to screening and intervention are limited by high costs, poor scalability and thus low impact on T2D burden. An intensive family-based lifestyle modification programme for the prevention of T2D was developed. The aim of the iHealth-T2D trial is to compare the effectiveness of this programme with usual care. Published version The research was supported by the European Union H2020 Program (iHealthT2D, 643774). JCC, JSK, GF, BR and WS are also supported in part by the National Institute for Health Research (NIHR) (16/136/68) using UK aid from the UK Government to support global health research. 2023-10-13T05:28:03Z 2023-10-13T05:28:03Z 2022 Journal Article Muilwijk, M., Loh, M., Mahmood, S., Palaniswamy, S., Siddiqui, S., Silva, W., Frost, G. S., Gage, H. M., Jarvelin, M., Rannan-Eliya, R. P., Ahmad, S., Jha, S., Kasturiratne, A., Katulanda, P., Khawaja, K. I., Kooner, J. S., Wickremasinghe, A. R., van Valkengoed, I. G. M. & Chambers, J. C. (2022). The iHealth-T2D study: a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes-a statistical analysis plan. Trials, 23(1), 755-. https://dx.doi.org/10.1186/s13063-022-06667-1 1745-6215 https://hdl.handle.net/10356/171103 10.1186/s13063-022-06667-1 36068618 2-s2.0-85137309588 1 23 755 en Trials © 2022 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Science::Medicine Type 2 Diabetes South Asian
spellingShingle	Science::Medicine Type 2 Diabetes South Asian Muilwijk, Mirthe Loh, Marie Mahmood, Sara Palaniswamy, Saranya Siddiqui, Samreen Silva, Wnurinham Frost, Gary S. Gage, Heather M. Jarvelin, Marjo-Riitta Rannan-Eliya, Ravindra P. Ahmad, Sajjad Jha, Sujeet Kasturiratne, Anuradhani Katulanda, Prasad Khawaja, Khadija I. Kooner, Jaspal S. Wickremasinghe, Ananda R. van Valkengoed, Irene G. M. Chambers, John Campbell The iHealth-T2D study: a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes-a statistical analysis plan
description	South Asians are at high risk of type 2 diabetes (T2D). Lifestyle modification is effective at preventing T2D amongst South Asians, but the approaches to screening and intervention are limited by high costs, poor scalability and thus low impact on T2D burden. An intensive family-based lifestyle modification programme for the prevention of T2D was developed. The aim of the iHealth-T2D trial is to compare the effectiveness of this programme with usual care.
author2	Lee Kong Chian School of Medicine (LKCMedicine)
author_facet	Lee Kong Chian School of Medicine (LKCMedicine) Muilwijk, Mirthe Loh, Marie Mahmood, Sara Palaniswamy, Saranya Siddiqui, Samreen Silva, Wnurinham Frost, Gary S. Gage, Heather M. Jarvelin, Marjo-Riitta Rannan-Eliya, Ravindra P. Ahmad, Sajjad Jha, Sujeet Kasturiratne, Anuradhani Katulanda, Prasad Khawaja, Khadija I. Kooner, Jaspal S. Wickremasinghe, Ananda R. van Valkengoed, Irene G. M. Chambers, John Campbell
format	Article
author	Muilwijk, Mirthe Loh, Marie Mahmood, Sara Palaniswamy, Saranya Siddiqui, Samreen Silva, Wnurinham Frost, Gary S. Gage, Heather M. Jarvelin, Marjo-Riitta Rannan-Eliya, Ravindra P. Ahmad, Sajjad Jha, Sujeet Kasturiratne, Anuradhani Katulanda, Prasad Khawaja, Khadija I. Kooner, Jaspal S. Wickremasinghe, Ananda R. van Valkengoed, Irene G. M. Chambers, John Campbell
author_sort	Muilwijk, Mirthe
title	The iHealth-T2D study: a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes-a statistical analysis plan
title_short	The iHealth-T2D study: a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes-a statistical analysis plan
title_full	The iHealth-T2D study: a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes-a statistical analysis plan
title_fullStr	The iHealth-T2D study: a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes-a statistical analysis plan
title_full_unstemmed	The iHealth-T2D study: a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes-a statistical analysis plan
title_sort	ihealth-t2d study: a cluster randomised trial for the prevention of type 2 diabetes amongst south asians with central obesity and prediabetes-a statistical analysis plan
publishDate	2023
url	https://hdl.handle.net/10356/171103
_version_	1781793732377444352

The iHealth-T2D study: a cluster randomised trial for the prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes-a statistical analysis plan

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