Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis

• Main Authors: Robinson, Kim Samirah, Toh, Gee Ann, Muhammad Jasrie Firdaus, Tham, Khek Chian, Rozario, Pritisha, Lim, Chrissie K., Toh, Ying Xiu, Lau, Zhi Heng, Binder, Sophie Charlotte, Mayer, Jacob, Bonnard, Carine, Schmidt, Florian I., Common, John E. A., Zhong, Franklin
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2023
• 主題: Science::Medicine; Diphtheria Toxin; Inflammasome
• 在線閱讀: https://hdl.handle.net/10356/171554

The ZAKα-driven ribotoxic stress response (RSR) is activated by ribosome stalling and/or collisions. Recent work demonstrates that RSR also plays a role in innate immunity by activating the human NLRP1 inflammasome. Here, we report that ZAKα and NLRP1 sense bacterial exotoxins that target ribosome e...