Diphtheria toxin activates ribotoxic stress and NLRP1 inflammasome-driven pyroptosis

• Main Authors: Robinson, Kim Samirah, Toh, Gee Ann, Muhammad Jasrie Firdaus, Tham, Khek Chian, Rozario, Pritisha, Lim, Chrissie K., Toh, Ying Xiu, Lau, Zhi Heng, Binder, Sophie Charlotte, Mayer, Jacob, Bonnard, Carine, Schmidt, Florian I., Common, John E. A., Zhong, Franklin
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Diphtheria Toxin; Inflammasome
• Online Access: https://hdl.handle.net/10356/171554
• Institution: Nanyang Technological University

The ZAKα-driven ribotoxic stress response (RSR) is activated by ribosome stalling and/or collisions. Recent work demonstrates that RSR also plays a role in innate immunity by activating the human NLRP1 inflammasome. Here, we report that ZAKα and NLRP1 sense bacterial exotoxins that target ribosome e...