Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis

• Main Authors: Pham, Thach Tuan, Le, Anh Hong, Dang, Cong Phi, Chong, Suet Yen, Do, Dang Vinh, Peng, Boya, Jayasinghe, Migara Kavishka, Ong, Hong Boon, Hoang, Dong Van, Louise, Roma Anne, Loh, Yuin-Han, Hou, Han Wei, Wang, Jiong-Wei, Le, Minh T. N.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; Atherosclerosis; Extracellular Vesicles
• Online Access: https://hdl.handle.net/10356/171610
• Institution: Nanyang Technological University

Extracellular vesicles (EVs) can be produced from red blood cells (RBCs) on a large scale and used to deliver therapeutic payloads efficiently. However, not much is known about the native biological properties of RBCEVs. Here, we demonstrate that RBCEVs are primarily taken up by macrophages and mono...