Urine leucine-rich α-2 glycoprotein 1 (LRG1) predicts the risk of progression to end-stage kidney disease in patients with type 2 diabetes

• Main Authors: Liu, Jian-Jun, Liu, Sylvia, Wang, Jiexun, Pek, Sharon L. T., Lee, Janus, Gurung, Resham L., Ang, Keven, Shao, Yi Ming, Tavintharan, Subramaniam, Tang, Wern Ee, Sum, Chee Fang, Lim, Su Chi
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2023
• Subjects: Science::Medicine; LRG1 Protein; End Stage Renal Disease
• Online Access: https://hdl.handle.net/10356/172167
• Institution: Nanyang Technological University

OBJECTIVE: Leucine-rich a-2 glycoprotein 1 (LRG1) was recently identified as an amplifier of transforming growth factor-b (TGF-b)–induced kidney fibrosis in animal models. We aimed to study whether urine LRG1 is associated with risk of progression to end-stage kidney disease (ESKD) in individuals wi...