Functional alterations of the prefrontal circuit underlying cognitive aging in mice

• Main Authors: Chong, Huee Ru, Ranjbar-Slamloo, Yadollah, Ho, Malcolm Zheng Hao, Ouyang, Xuan, Kamigaki, Tsukasa
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Cognitive Aging; Prefrontal Cortex
• Online Access: https://hdl.handle.net/10356/173002
• Institution: Nanyang Technological University

Executive function is susceptible to aging. How aging impacts the circuit-level computations underlying executive function remains unclear. Using calcium imaging and optogenetic manipulation during memory-guided behavior, we show that working-memory coding and the relevant recurrent connectivity in...