Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers

• Main Authors: Lau, Hannah Si Hui, Tan, Veronique Kiak Mien, Tan, Benita Kiat Tee, Sim, Yirong, Quist, Jelmar, Thike, Aye Aye, Tan, Puay Hoon, Pervaiz, Shazib, Grigoriadis, Anita, Sabapathy, Kanaga
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Science::Medicine; Science::Biological sciences; Progesterone Receptor; Breast Cancer
• Online Access: https://hdl.handle.net/10356/173163
• Institution: Nanyang Technological University

Despite our understanding of the genetic basis of intra-tumoral heterogeneity, the role of stromal heterogeneity arising from an altered tumor microenvironment in affecting tumorigenesis is poorly understood. In particular, extensive study on the peri-tumoral stroma in the morphologically normal tis...