Fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/DABCO catalytic system

Fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/DABCO catalytic system

A novel organophotoredox/DABCO catalytic system for the fluoroalkylation of activated allylic acetates via radical-radical coupling is described. The method offers mild reaction conditions, high selectivity, and broad substrate compatibility and enabled diverse bioactive molecules, FDA-approved drug...

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Main Authors: Zhang, Xiaoyu, Zhang, Yinlei, Li, Xiaohong, Li, Bowen, Xiao, Shiji, Tang, Yongming, Xie, Peizhong, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2024
Subjects:
Science::Chemistry
Organophotoredox/DABCO Catalytic System
Fluoroalkylation
Online Access:https://hdl.handle.net/10356/173298
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1732982024-01-24T01:00:00Z Fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/DABCO catalytic system Zhang, Xiaoyu Zhang, Yinlei Li, Xiaohong Li, Bowen Xiao, Shiji Tang, Yongming Xie, Peizhong Loh, Teck-Peng School of Physical and Mathematical Sciences Science::Chemistry Organophotoredox/DABCO Catalytic System Fluoroalkylation A novel organophotoredox/DABCO catalytic system for the fluoroalkylation of activated allylic acetates via radical-radical coupling is described. The method offers mild reaction conditions, high selectivity, and broad substrate compatibility and enabled diverse bioactive molecules, FDA-approved drugs, and amino acid derivatives to be incorporated into transformation. This study expands the synthetic toolbox for the construction of fluorine-containing molecules. We gratefully acknowledge financial support from the National Natural Science Foundation of China (21702108), the Natural Science Foundation of Jiangsu Province, China (BK20211257), and the Six Talent Peaks Project in Jiangsu Province (YY-033). 2024-01-24T01:00:00Z 2024-01-24T01:00:00Z 2023 Journal Article Zhang, X., Zhang, Y., Li, X., Li, B., Xiao, S., Tang, Y., Xie, P. & Loh, T. (2023). Fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/DABCO catalytic system. Organic Letters, 25(37), 6863-6868. https://dx.doi.org/10.1021/acs.orglett.3c02456 1523-7060 https://hdl.handle.net/10356/173298 10.1021/acs.orglett.3c02456 37681688 2-s2.0-85172033785 37 25 6863 6868 en Organic Letters © 2023 American Chemical Society. All rights reserved.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Organophotoredox/DABCO Catalytic System
Fluoroalkylation
spellingShingle Science::Chemistry
Organophotoredox/DABCO Catalytic System
Fluoroalkylation
Zhang, Xiaoyu
Zhang, Yinlei
Li, Xiaohong
Li, Bowen
Xiao, Shiji
Tang, Yongming
Xie, Peizhong
Loh, Teck-Peng
Fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/DABCO catalytic system
description A novel organophotoredox/DABCO catalytic system for the fluoroalkylation of activated allylic acetates via radical-radical coupling is described. The method offers mild reaction conditions, high selectivity, and broad substrate compatibility and enabled diverse bioactive molecules, FDA-approved drugs, and amino acid derivatives to be incorporated into transformation. This study expands the synthetic toolbox for the construction of fluorine-containing molecules.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Zhang, Xiaoyu
Zhang, Yinlei
Li, Xiaohong
Li, Bowen
Xiao, Shiji
Tang, Yongming
Xie, Peizhong
Loh, Teck-Peng
format Article
author Zhang, Xiaoyu
Zhang, Yinlei
Li, Xiaohong
Li, Bowen
Xiao, Shiji
Tang, Yongming
Xie, Peizhong
Loh, Teck-Peng
author_sort Zhang, Xiaoyu
title Fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/DABCO catalytic system
title_short Fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/DABCO catalytic system
title_full Fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/DABCO catalytic system
title_fullStr Fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/DABCO catalytic system
title_full_unstemmed Fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/DABCO catalytic system
title_sort fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/dabco catalytic system
publishDate 2024
url https://hdl.handle.net/10356/173298
_version_ 1789482874572898304

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