Fluoroalkylation of activated allylic acetates through radical-radical coupling: organophotoredox/DABCO catalytic system

• Main Authors: Zhang, Xiaoyu, Zhang, Yinlei, Li, Xiaohong, Li, Bowen, Xiao, Shiji, Tang, Yongming, Xie, Peizhong, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Science::Chemistry; Organophotoredox/DABCO Catalytic System; Fluoroalkylation
• Online Access: https://hdl.handle.net/10356/173298
• Institution: Nanyang Technological University

A novel organophotoredox/DABCO catalytic system for the fluoroalkylation of activated allylic acetates via radical-radical coupling is described. The method offers mild reaction conditions, high selectivity, and broad substrate compatibility and enabled diverse bioactive molecules, FDA-approved drug...