DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11

DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11

The scaffolding protein CARD11 is a critical mediator of antigen receptor signaling in lymphocytes. Hypomorphic (partial loss-of-function) mutations in CARD11 are associated with the development of severe atopic dermatitis, in which T cell receptor signaling is reduced and helper T cell differentiat...

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Bibliographic Details
Main Authors: Loh Jia Tong, Teo, Joey Kay Hui, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Andiappan, Anand Kumar, Lim, Hong-Hwa, Lam, Kong-Peng
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2024
Subjects:
Mathematical Sciences
Adaptor Proteins
Phosphoric Monoester Hydrolases
Online Access:https://hdl.handle.net/10356/173519
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/173519

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