DOK3 promotes atopic dermatitis by enabling the phosphatase PP4C to inhibit the T cell signaling mediator CARD11

• Main Authors: Loh Jia Tong, Teo, Joey Kay Hui, Kannan, Srinivasaraghavan, Verma, Chandra Shekhar, Andiappan, Anand Kumar, Lim, Hong-Hwa, Lam, Kong-Peng
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Mathematical Sciences; Adaptor Proteins; Phosphoric Monoester Hydrolases
• Online Access: https://hdl.handle.net/10356/173519
• Institution: Nanyang Technological University

The scaffolding protein CARD11 is a critical mediator of antigen receptor signaling in lymphocytes. Hypomorphic (partial loss-of-function) mutations in CARD11 are associated with the development of severe atopic dermatitis, in which T cell receptor signaling is reduced and helper T cell differentiat...