The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo

• Main Authors: Hernández-Quiles, Miguel, Campesino, Laura Martinez, Morris, Imogen, Ilyas, Zabran, Reynolds, Steve, Tan, Nguan Soon, Alcaraz, Paula Sobrevals, Stigter, Edwin C. A., Varga, Ákos, Varga, János, van Es, Robert, Vos, Harmjan, Wilson, Heather L., Kiss-Toth, Endre, Kalkhoven, Eric
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Tribbles; Adipocyte
• Online Access: https://hdl.handle.net/10356/173877
• Institution: Nanyang Technological University

Objective: In vivo studies in humans and mice have implicated the pseudokinase Tribbles 3 (TRIB3) in various aspects of energy metabolism. Whilst cell-based studies indicate a role for TRIB3 in adipocyte differentiation and function, it is unclear if and how these cellular functions may contribute t...