Single-cell transcriptomics reveals maturation of transplanted stem cell–derived retinal pigment epithelial cells toward native state

• Main Authors: Parikh, Bhav Harshad, Blakeley, Paul, Regha, Kakkad, Liu, Zengping, Yang, Binxia, Bhargava, Mayuri, Wong, Daniel Soo Lin, Tan, Queenie Shu Woon, Wong, Claudine See Wei, Wang, Hao Fei, Al-Mubaarak, Abdurrahmaan, Chou, Chai, Cheung, Gemmy Chui Ming, Lim Kah-Leong, Barathi, Veluchamy Amutha, Hunziker, Walter, Lingam, Gopal, Hu, Tim Xiaoming, Su, Xinyi
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Pluripotent stem cell; Retinal pigment epithelium
• Online Access: https://hdl.handle.net/10356/174340
• Institution: Nanyang Technological University

Transplantation of stem cell–derived retinal pigment epithelial (RPE) cells is considered a viable therapeutic option for age-related macular degeneration (AMD). Several landmark Phase I/II clinical trials have demonstrated safety and tolerability of RPE transplants in AMD patients, albeit with limi...