Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma

• Main Authors: Mizokami, Harue, Okabe, Atsushi, Choudhary, Ruchi, Mima, Masato, Saeda, Kenta, Fukuyo, Masaki, Rahmutulla, Bahityar, Seki, Motoaki, Goh, Boon-Cher, Kondo, Satoru, Dochi, Hirotomo, Moriyama-Kita, Makiko, Misawa, Kiyoshi, Hanazawa, Toyoyuki, Tan, Patrick, Yoshizaki, Tomokazu, Fullwood, Melissa Jane, Kaneda, Atsushi
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Epstein-Barr virus; Nasopharyngeal carcinoma; Enhancer infestation
• Online Access: https://hdl.handle.net/10356/174488
• Institution: Nanyang Technological University

Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignant epithelial tumor endemic to Southern China and Southeast Asia. While previous studies have revealed a low frequency of gene mutations in NPC, its epigenomic aberrations are not fully elucidated apart from DNA hypermethylation. Epigenomic rewiring and enhancer dysregulation, such as enhancer hijacking due to genomic structural changes or extrachromosomal DNA, drive cancer progression.