Mutation detection of urinary cell-free DNA via catch-and-release isolation on nanowires for liquid biopsy

• Main Authors: Takahashi, Hiromi, Yasui, Takao, Hirano, Masaki, Shinjo, Keiko, Miyazaki, Yusuke, Shinoda, Wataru, Hasegawa, Takeshi, Natsume, Atsushi, Kitano, Yotaro, Ida, Mikiko, Zhang, Min, Shimada, Taisuke, Paisrisarn, Piyawan, Zhu, Zetao, Ohka, Fumiharu, Aoki, Kosuke, Rahong, Sakon, Nagashima, Kazuki, Yanagida, Takeshi, Baba, Yoshinobu
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2024
• Subjects: Engineering; Cell-free DNA; Extracellular vesicles
• Online Access: https://hdl.handle.net/10356/174543
• Institution: Nanyang Technological University

Cell-free DNA (cfDNA) and extracellular vesicles (EVs) are molecular biomarkers in liquid biopsies that can be applied for cancer detection, which are known to carry information on the necessary conditions for oncogenesis and cancer cell-specific activities after oncogenesis, respectively. Analyses...