Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma

• Main Authors: Liu, Min, Bertolazzi, Giorgio, Sridhar, Shruti, Lee, Rui Xue, Jaynes, Patrick, Mulder, Kevin, Syn, Nicholas, Hoppe, Michal Marek, Fan, Shuangyi, Peng, Yanfen, Thng, Jocelyn, Chua, Reiya, Jayalakshmi, Batumalai, Yogeshini, De Mel, Sanjay, Poon, Limei, Chan, Esther Hian Li, Lee, Joanne, Hue, Susan Swee-Shan, Chang, Sheng-Tsung, Chuang, Shih-Sung, Chandy, Kanianthara George, Ye, Xiaofei, Pan-Hammarström, Qiang, Ginhoux, Florent, Chee, Yen Lin, Ng, Siok-Bian, Tripodo, Claudio, Jeyasekharan, Anand D.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Cancer prognosis; Cell heterogeneity
• Online Access: https://hdl.handle.net/10356/174908
• Institution: Nanyang Technological University

Macrophages are abundant immune cells in the microenvironment of diffuse large B-cell lymphoma (DLBCL). Macrophage estimation by immunohistochemistry shows varying prognostic significance across studies in DLBCL, and does not provide a comprehensive analysis of macrophage subtypes. Here, using digit...