Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL)

Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL)

During cancer growth and metastasis, large demand of biomass often results in cancer cells encountering lack of nutrients. The lack of extracellular amino acids can lead to the induction of the integrated stress response (ISR). The ISR is mediated by phosphorylated eIF2-alpha (eIF2α) and activating...

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Main Author: Zhang, Jiexin
Other Authors: -
Format: Final Year Project
Language:English
Published: Nanyang Technological University 2024
Subjects:
Medicine, Health and Life Sciences
Online Access:https://hdl.handle.net/10356/176175
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1761752024-05-30T06:48:46Z Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL) Zhang, Jiexin - School of Biological Sciences Wang Liang Wei Wang_Liang_Wei@immunol.a-star.edu.sg Medicine, Health and Life Sciences During cancer growth and metastasis, large demand of biomass often results in cancer cells encountering lack of nutrients. The lack of extracellular amino acids can lead to the induction of the integrated stress response (ISR). The ISR is mediated by phosphorylated eIF2-alpha (eIF2α) and activating transcription factor 4 (ATF4), with the latter transactivating target genes in numerous pathways, including that of De Novo Serine Synthesis (DNSS). This project focuses on elucidating the mechanism of this pathway in NKTL. Bachelor's degree 2024-05-30T06:48:46Z 2024-05-30T06:48:46Z 2024 Final Year Project (FYP) Zhang, J. (2024). Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL). Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/176175 https://hdl.handle.net/10356/176175 en application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Medicine, Health and Life Sciences
spellingShingle Medicine, Health and Life Sciences
Zhang, Jiexin
Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL)
description During cancer growth and metastasis, large demand of biomass often results in cancer cells encountering lack of nutrients. The lack of extracellular amino acids can lead to the induction of the integrated stress response (ISR). The ISR is mediated by phosphorylated eIF2-alpha (eIF2α) and activating transcription factor 4 (ATF4), with the latter transactivating target genes in numerous pathways, including that of De Novo Serine Synthesis (DNSS). This project focuses on elucidating the mechanism of this pathway in NKTL.
author2 -
author_facet -
Zhang, Jiexin
format Final Year Project
author Zhang, Jiexin
author_sort Zhang, Jiexin
title Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL)
title_short Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL)
title_full Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL)
title_fullStr Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL)
title_full_unstemmed Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL)
title_sort epigenetic landscapes of de novo serine synthesis pathway in natural killer/t cell lymphoma (nktl)
publisher Nanyang Technological University
publishDate 2024
url https://hdl.handle.net/10356/176175
_version_ 1800916292327178240

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