Epigenetic landscapes of De Novo Serine synthesis pathway in natural killer/T cell lymphoma (NKTL)

• Main Author: Zhang, Jiexin
• Other Authors: -
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2024
• Subjects: Medicine, Health and Life Sciences
• Online Access: https://hdl.handle.net/10356/176175
• Institution: Nanyang Technological University

During cancer growth and metastasis, large demand of biomass often results in cancer cells encountering lack of nutrients. The lack of extracellular amino acids can lead to the induction of the integrated stress response (ISR). The ISR is mediated by phosphorylated eIF2-alpha (eIF2α) and activating...