Synergistic copper-aminocatalysis for direct tertiary -alkylation of ketones with electron-deficient alkanes

In this study, a novel approach for the tertiary α-alkylation of ketones using alkanes with electron-deficient C─H bonds is presented, employing a synergistic catalytic system combining inexpensive copper salts with aminocatalysis. This methodology addresses the limitations of traditional alkylation...

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Bibliographic Details
Main Authors: Shan, Qi-Chao, Wu, You-Wei, Chen, Mu-Xiang, Zhao, Xuefei, Loh, Teck-Peng, Hu, Xu-Hong
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2024
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Online Access:https://hdl.handle.net/10356/178845
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Institution: Nanyang Technological University
Language: English