Morphological multiparameter filtration and persistent homology in mitochondrial image analysis

• Main Authors: Chung, Yu-Min, Hu, Chuan-Shen, Sun, Emily, Tseng, Henry C.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Mathematical Sciences; Amyotrophic lateral sclerosis; Confocal microscopy
• Online Access: https://hdl.handle.net/10356/180474
• Institution: Nanyang Technological University

The complexity of branching and curvilinear morphology of a complete mitochondrial network within each cell is challenging to analyze and quantify. To address this challenge, we developed an image analysis technique using persistent homology with a multiparameter filtration framework, combining imag...