Carbene and photocatalyst-catalyzed 3-acylation of indoles for facile access to indole-3-yl aryl ketones

• Main Authors: Tu, Ting, Nie, GuiHua, Zhang, Tinglei, Hu, Chunmei, Ren, Shi-Chao, Xia, Huimin, Chi, Robin Yonggui
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Aryl ketones; Carbenes
• Online Access: https://hdl.handle.net/10356/181030
• Institution: Nanyang Technological University

3-Acyl indoles play important roles in both organic synthesis and diverse types of functional molecules. Herein, a facile nitrogen heterocyclic carbene (NHC) and photocatalyst cooperatively-catalyzed 3-acylation of indoles was disclosed. The reaction proceeded via radical cross-coupling of indole-ba...