Photocatalytic decarboxylative allylation of α-amino acids and peptides under metal-free conditions

Photocatalytic decarboxylative allylation of α-amino acids and peptides under metal-free conditions

We developed an organophotoredox catalytic system to facilitate the decarboxylative allylation coupling process concerning α-amino acids and related C-terminal carboxylate peptides using Morita-Baylis-Hillman adducts as allylic precursors. This metal-free method operates under mild conditions and is...

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Bibliographic Details
Main Authors: Zhang, Yinlei, Lu, Yanyu, Ju, Chengyang, Zhang, Zhenguo, Wang, Dongping, Wang, Shirui, Xie, Peizhong, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2024
Subjects:
Chemistry
Allyl compound
Amino acid
Online Access:https://hdl.handle.net/10356/181037
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Institution: Nanyang Technological University
Language: English
Description
Summary:We developed an organophotoredox catalytic system to facilitate the decarboxylative allylation coupling process concerning α-amino acids and related C-terminal carboxylate peptides using Morita-Baylis-Hillman adducts as allylic precursors. This metal-free method operates under mild conditions and is compatible with various amino acids. The versatility of this protocol, particularly in chemical biology research, has been preliminarily demonstrated through the ligation of bioactive peptide chains.

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