Photocatalytic decarboxylative allylation of α-amino acids and peptides under metal-free conditions

• Main Authors: Zhang, Yinlei, Lu, Yanyu, Ju, Chengyang, Zhang, Zhenguo, Wang, Dongping, Wang, Shirui, Xie, Peizhong, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Allyl compound; Amino acid
• Online Access: https://hdl.handle.net/10356/181037
• Institution: Nanyang Technological University

We developed an organophotoredox catalytic system to facilitate the decarboxylative allylation coupling process concerning α-amino acids and related C-terminal carboxylate peptides using Morita-Baylis-Hillman adducts as allylic precursors. This metal-free method operates under mild conditions and is...