Sustained antibiotic release from biodegradable gelatin–silica hybrid for orthopedic infections

• Main Authors: Lin, Yu-Chien, Lee, Chin-Yun, Jones, Julian R., Liu, Wai-Ching, Cho, Nam-Joon, Hu, Chih-Chien, Chung, Ren-Jei
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2024
• Subjects: Engineering; Antibacterial activity; Biodegradable
• Online Access: https://hdl.handle.net/10356/181065
• Institution: Nanyang Technological University

Antibiotic-loaded polymethylmethacrylate (PMMA) beads are commonly employed to treat prosthetic joint infections (PJI) and chronic osteomyelitis due to their excellent mechanical strength. However, PMMA's non-degradability results in a burst release of antibiotics and potential renal toxicity,...