Phase-separating peptide coacervates with programmable material properties for universal intracellular delivery of macromolecules

• Main Authors: Sun, Yue, Wu, Xi, Li, Jianguo, Radiom, Milad, Mezzenga, Raffaele, Verma, Chandra Shekhar, Yu, Jing, Miserez, Ali
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2025
• Subjects: Medicine, Health and Life Sciences; Amino acid sequence; Cell membrane
• Online Access: https://hdl.handle.net/10356/182044
• Institution: Nanyang Technological University

Phase-separating peptides (PSPs) self-assembling into coacervate microdroplets (CMs) are a promising class of intracellular delivery vehicles that can release macromolecular modalities deployed in a wide range of therapeutic treatments. However, the molecular grammar governing intracellular uptake a...