Fabrication and characterization of barium strontium titanate film based biosensor

• Main Author: Tan, Lay Im
• Other Authors: Gan-Yap Yik Yuen
• Format: Theses and Dissertations
• Language: English
• Published: 2009
• Subjects: DRNTU::Engineering::Electrical and electronic engineering
• Online Access: https://hdl.handle.net/10356/20679
• Institution: Nanyang Technological University

In this project, biosensors based on a sol-gel derived Barium Strontium Titanate (BST) composite film are studied. Poly(TMS-r-NHS) [TMS: 3-(trimethoxysilyl)propyl methacrylate; NHS: N-hydroxysuccinimide] is used to modify the BST surface for protein immobilization. Two types of biosensors were developed and investigated. First, Bovine Serum Albumin (BSA) was immobilized on the poly(TMS-r-NHS) followed by anti-BSA. On the second type of biosensors, cloned Epstein-Barr virus (EBV) was imlTIobilized on the poly(TMS-r-NHS) followed by anti-EBV. Significant impedance increlnents were observed on both biosensors. These impedance increments were attributed to three factors.