Copper-catalysed β-silylation of α,β-unsaturated esters under mild reaction conditions.

A highly-efficient β-silylation of α, β-unsaturated esters was developed, utilizing N-heterocyclic carbene copper(I) catalyst via a unique protocol based on Si ̶B activation. By employing MeOH as a basic additive which is necessary to promote the reaction, the β-silylation products can be readily ob...

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Main Author:	Siti Suhaila Sulaiman.
Other Authors:	Loh Teck Peng
Format:	Final Year Project
Language:	English
Published:	2010
Subjects:	DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds
Online Access:	http://hdl.handle.net/10356/38631
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-38631
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spelling	sg-ntu-dr.10356-386312023-02-28T23:13:20Z Copper-catalysed β-silylation of α,β-unsaturated esters under mild reaction conditions. Siti Suhaila Sulaiman. Loh Teck Peng School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds A highly-efficient β-silylation of α, β-unsaturated esters was developed, utilizing N-heterocyclic carbene copper(I) catalyst via a unique protocol based on Si ̶B activation. By employing MeOH as a basic additive which is necessary to promote the reaction, the β-silylation products can be readily obtained. All the reactions proceeded at room temperature with good yields. A mechanistic cycle has been proposed to account for the process. Bachelor of Science in Chemistry and Biological Chemistry 2010-05-14T01:10:47Z 2010-05-14T01:10:47Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/38631 en 48 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds
spellingShingle	DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds Siti Suhaila Sulaiman. Copper-catalysed β-silylation of α,β-unsaturated esters under mild reaction conditions.
description	A highly-efficient β-silylation of α, β-unsaturated esters was developed, utilizing N-heterocyclic carbene copper(I) catalyst via a unique protocol based on Si ̶B activation. By employing MeOH as a basic additive which is necessary to promote the reaction, the β-silylation products can be readily obtained. All the reactions proceeded at room temperature with good yields. A mechanistic cycle has been proposed to account for the process.
author2	Loh Teck Peng
author_facet	Loh Teck Peng Siti Suhaila Sulaiman.
format	Final Year Project
author	Siti Suhaila Sulaiman.
author_sort	Siti Suhaila Sulaiman.
title	Copper-catalysed β-silylation of α,β-unsaturated esters under mild reaction conditions.
title_short	Copper-catalysed β-silylation of α,β-unsaturated esters under mild reaction conditions.
title_full	Copper-catalysed β-silylation of α,β-unsaturated esters under mild reaction conditions.
title_fullStr	Copper-catalysed β-silylation of α,β-unsaturated esters under mild reaction conditions.
title_full_unstemmed	Copper-catalysed β-silylation of α,β-unsaturated esters under mild reaction conditions.
title_sort	copper-catalysed β-silylation of α,β-unsaturated esters under mild reaction conditions.
publishDate	2010
url	http://hdl.handle.net/10356/38631
_version_	1759854530199027712

Copper-catalysed β-silylation of α,β-unsaturated esters under mild reaction conditions.

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