The activation states of LFA-1 (αLβ2) and related integrins
Cell adhesion molecules, which are both receptors and ligands for receptors, are typically transmembrane proteins. They are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain and an extracellular domain that interacts either with other cel...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2010
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| Online Access: | https://hdl.handle.net/10356/38777 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Cell adhesion molecules, which are both receptors and ligands for receptors, are typically transmembrane proteins. They are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain and an extracellular domain that interacts either with other cell adhesion molecules on another cell or the component of the extracellular matrix (ECM) (Joseph-Silverstein and Silverstein, 1998). Their functions include adhesion, recognition and communication between cells and between cells and components of the extracellular matrix. |
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