Stability of peptide nucleic acid influenced by peptoid-like sidechains : MD simulation study.

• Main Author: Yeo, Sven Hwea Jie.
• Other Authors: Mu Yuguang
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/38930
• Institution: Nanyang Technological University

Peptide nucleic acid (PNA) is one of the most promising candidates for next-generation antisense technology. Other than high specificity and ability to be engineered to target, it offers enhanced stability, fidelity and strand invasion capabilities. Rapid developments in this field include synthesis...