Structural studies with novel ruthenium anticancer agents.

• Main Author: Soon, Cin Huang.
• Other Authors: Curtis Alexander Davey
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/39540
• Institution: Nanyang Technological University

In this study, we aim to obtain the crystal structure of the ruthenium based anticancer agents which will provide us a better understand on the drug’s mechanism of action. Two ruthenium based drugs, RuCl2(η6-p-cymene)-(PTA), (PTA = 1,3,5-triaza-7-phosphaadamantane) or RAPTA-C and Hind[trans-RuCl4(in...