Dissection of mechanistic action of anticancer multidrug resistance reversal agents from a natural product library.

• Main Author: Ong, Yi Jun.
• Other Authors: Zhao Yan
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Drug Resistance
• Online Access: http://hdl.handle.net/10356/39580
• Institution: Nanyang Technological University

The phenomenon of multidrug resistant (MDR) ovarian cancer is a major obstacle to successful cancer treatment. Thapsigargin, a natural sesquiterpene lactone, has been studied for its MDR reversal effects against MDR cancers by inducing endoplasmic recticulum stress and cell death. In this study, we...