Mechanism of sensing antimicrobial peptides by bacteria : towards a structural understanding ; LPS-bound structures of designed peptides : effects of incorporation of β-turn nucleating amino acids (D-Pro and Asn).

• Main Author: Lim, Seng Koon.
• Other Authors: Surajit Bhattacharyya
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: http://hdl.handle.net/10356/39735
• Institution: Nanyang Technological University

The Aps system, consisting of a transmembrane sensor protein ApsS and two cytosolic ApsX and ApsR, is responsible for antimicrobial peptides (AMPs) resistance mechanism in Gram-positive bacteria. The ApsS acts as a sensor to have direct interactions with AMPs through its extra-cellular loop connecte...