A combined bioinformatics and experimental approach towards the molecular phenotype of disease-causing single point mutations.
Towards unravelling the enigmatic sequence-structure-function relationship, this study presents a computational-experimental strategy to characterise the effects of disease mutations on protein structure stability and misfolding phenotypes. Firstly, suitable candidates from normally secreted human p...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2010
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| Online Access: | http://hdl.handle.net/10356/40118 |
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| Institution: | Nanyang Technological University |
| Language: | English |