A combined bioinformatics and experimental approach towards the molecular phenotype of disease-causing single point mutations.

• Main Author: Lim, Radiance Hui Ting.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: http://hdl.handle.net/10356/40118
• Institution: Nanyang Technological University

Towards unravelling the enigmatic sequence-structure-function relationship, this study presents a computational-experimental strategy to characterise the effects of disease mutations on protein structure stability and misfolding phenotypes. Firstly, suitable candidates from normally secreted human p...