Mn(III)-catalyzed synthesis of pyrroles from vinyl azides and B-keto acids.

• Main Author: Ng, Eileen Pei Jian.
• Other Authors: Chiba Shunsuke
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
• Online Access: http://hdl.handle.net/10356/40466
• Institution: Nanyang Technological University

β-keto acids and vinyl azides are found to be promising precursors for the synthesis of pyrroles with Mn(acac)3 as a catalyst. One electron oxidation of β-keto acids by Mn(acac)3 induces decarboxylation to afford α-keto radicals, which then add on to vinyl azides, leading to the formation of iminyl...