Application of COLD-PCR for improved detection of EGFR mutations in clinical samples.

• Main Author: Zhang, Zhi Xuan.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/41758
• Institution: Nanyang Technological University

Due to the significance of mutation status of the epidermal growth factor receptor (EGFR) gene in non-small-cell lung cancer (NSCLC) affecting patient response to tyrosine kinase inhibitors (TKI), the more sensitive and robust the method used to detect the mutations, the better. It has been suggeste...