Pharmacogenetics of VKORC1 in warfarin resistant patients.

• Main Author: Ong, Jacqueline Kai Mei.
• Other Authors: Balram Chowbay
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Drug Resistance
• Online Access: http://hdl.handle.net/10356/41759
• Institution: Nanyang Technological University

Warfarin is a commonly prescribed anticoagulant that displays wide inter-individual variability in treatment response and dosage. It acts by inhibiting the vitamin K epoxide reductase (VKOR) enzyme in the liver. Genetic variations in vitamin K epoxide reductase complex subunit 1(VKORC1), have been a...