Pharmacogenetics of VKORC1 in warfarin resistant patients.

• 主要作者: Ong, Jacqueline Kai Mei.
• 其他作者: Balram Chowbay
• 格式: Final Year Project
• 語言: English
• 出版: 2010
• 主題: DRNTU::Science::Biological sciences::Microbiology::Drug Resistance
• 在線閱讀: http://hdl.handle.net/10356/41759
• 機構: Nanyang Technological University

Warfarin is a commonly prescribed anticoagulant that displays wide inter-individual variability in treatment response and dosage. It acts by inhibiting the vitamin K epoxide reductase (VKOR) enzyme in the liver. Genetic variations in vitamin K epoxide reductase complex subunit 1(VKORC1), have been a...