Pharmacogenetics of VKORC1 in warfarin resistant patients.

• المؤلف الرئيسي: Ong, Jacqueline Kai Mei.
• مؤلفون آخرون: Balram Chowbay
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2010
• الموضوعات: DRNTU::Science::Biological sciences::Microbiology::Drug Resistance
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/41759
• المؤسسة: Nanyang Technological University

Warfarin is a commonly prescribed anticoagulant that displays wide inter-individual variability in treatment response and dosage. It acts by inhibiting the vitamin K epoxide reductase (VKOR) enzyme in the liver. Genetic variations in vitamin K epoxide reductase complex subunit 1(VKORC1), have been a...