An in silico, in vitro and in vivo study of the structural and functional features of SARS small protein E and its contribution to viral morphogenesis and apoptosis.

Severe acute respiratory syndrome (SARS) is a respiratory disease in humans caused by the SARS coronavirus (SCoV). All coronaviruses encode a small hydrophobic envelope (E) protein, which mediates viral assembly and morphogenesis by an unknown mechanism. When E proteins are synthesized alone, the...

Full description

Saved in:
Bibliographic Details
Main Author: Torres, Jaume.
Other Authors: School of Biological Sciences
Format: Research Report
Language:English
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/10356/41873
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-41873
record_format dspace
spelling sg-ntu-dr.10356-418732023-02-28T17:58:26Z An in silico, in vitro and in vivo study of the structural and functional features of SARS small protein E and its contribution to viral morphogenesis and apoptosis. Torres, Jaume. School of Biological Sciences DRNTU::Science::Biological sciences::Microbiology::Virology Severe acute respiratory syndrome (SARS) is a respiratory disease in humans caused by the SARS coronavirus (SCoV). All coronaviruses encode a small hydrophobic envelope (E) protein, which mediates viral assembly and morphogenesis by an unknown mechanism. When E proteins are synthesized alone, they reconfigure intracellular membranous organelles or induce secretion of exosomal vesicles when overexpressed. However, their precise function remains elusive. Indeed, although they promote coronavirus assembly, they are not absolutely required. Additionally, it has been found that E proteins of several different coronaviruses, despite having amino acid identities of only about 200/0, substitute for MHV E and provide growth for MHV lacking E. This suggests that E proteins do not have typespecific interacting virion assembly partners, e.g., M or S proteins. ARC 7/05 2010-08-27T04:07:46Z 2010-08-27T04:07:46Z 2008 2008 Research Report http://hdl.handle.net/10356/41873 en 28 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Microbiology::Virology
spellingShingle DRNTU::Science::Biological sciences::Microbiology::Virology
Torres, Jaume.
An in silico, in vitro and in vivo study of the structural and functional features of SARS small protein E and its contribution to viral morphogenesis and apoptosis.
description Severe acute respiratory syndrome (SARS) is a respiratory disease in humans caused by the SARS coronavirus (SCoV). All coronaviruses encode a small hydrophobic envelope (E) protein, which mediates viral assembly and morphogenesis by an unknown mechanism. When E proteins are synthesized alone, they reconfigure intracellular membranous organelles or induce secretion of exosomal vesicles when overexpressed. However, their precise function remains elusive. Indeed, although they promote coronavirus assembly, they are not absolutely required. Additionally, it has been found that E proteins of several different coronaviruses, despite having amino acid identities of only about 200/0, substitute for MHV E and provide growth for MHV lacking E. This suggests that E proteins do not have typespecific interacting virion assembly partners, e.g., M or S proteins.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Torres, Jaume.
format Research Report
author Torres, Jaume.
author_sort Torres, Jaume.
title An in silico, in vitro and in vivo study of the structural and functional features of SARS small protein E and its contribution to viral morphogenesis and apoptosis.
title_short An in silico, in vitro and in vivo study of the structural and functional features of SARS small protein E and its contribution to viral morphogenesis and apoptosis.
title_full An in silico, in vitro and in vivo study of the structural and functional features of SARS small protein E and its contribution to viral morphogenesis and apoptosis.
title_fullStr An in silico, in vitro and in vivo study of the structural and functional features of SARS small protein E and its contribution to viral morphogenesis and apoptosis.
title_full_unstemmed An in silico, in vitro and in vivo study of the structural and functional features of SARS small protein E and its contribution to viral morphogenesis and apoptosis.
title_sort in silico, in vitro and in vivo study of the structural and functional features of sars small protein e and its contribution to viral morphogenesis and apoptosis.
publishDate 2010
url http://hdl.handle.net/10356/41873
_version_ 1759856175302574080