Part I Towards a total synthesis of papulacandin D Part II Towards a total synthesis of amphidinolide X

• Main Author: Goh, Hong Heng
• Other Authors: Bernard Leung
• Format: Theses and Dissertations
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
• Online Access: https://hdl.handle.net/10356/42901
• Institution: Nanyang Technological University

The facile β,γ- to α,β-isomerization upon hydrolysis of the three-carbon homologated Wittig olefination product using the homoenolate anion equivalent (3,3 dimethoxypropyl) triphenylphosphonium salt has always been viewed as a complicating side reaction in organic synthesis. Perhaps arising from such...