Design and synthesis of an orally active biologic based on cyclic ω-conotoxin MVIIA-GS.

MVIIA is a peptide isolated from cone snail venom. It is a potent inhibitor of N-type voltage-gated calcium channels on presynaptic neurons, preventing release of neurotransmitters for pain signal transmission. Its synthetic form Ziconotide has been approved for clinical therapy but can only be admi...

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Bibliographic Details
Main Author: Koh, Samantha Qian Ping.
Other Authors: Jimmy Pingkwan Tam @ James P Tam
Format: Final Year Project
Language:English
Published: 2011
Subjects:
Online Access:http://hdl.handle.net/10356/44537
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Institution: Nanyang Technological University
Language: English