Design and synthesis of an orally active biologic based on cyclic ω-conotoxin MVIIA-GS.

• Main Author: Koh, Samantha Qian Ping.
• Other Authors: Jimmy Pingkwan Tam @ James P Tam
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences
• Online Access: http://hdl.handle.net/10356/44537
• Institution: Nanyang Technological University

MVIIA is a peptide isolated from cone snail venom. It is a potent inhibitor of N-type voltage-gated calcium channels on presynaptic neurons, preventing release of neurotransmitters for pain signal transmission. Its synthetic form Ziconotide has been approved for clinical therapy but can only be admi...