Design and synthesis of an orally active biologic based on cyclic ω-conotoxin MVIIA-GS.
MVIIA is a peptide isolated from cone snail venom. It is a potent inhibitor of N-type voltage-gated calcium channels on presynaptic neurons, preventing release of neurotransmitters for pain signal transmission. Its synthetic form Ziconotide has been approved for clinical therapy but can only be admi...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project |
| Language: | English |
| Published: |
2011
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/44537 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |