Design and synthesis of an orally active biologic based on cyclic ω-conotoxin MVIIA-GS.

• المؤلف الرئيسي: Koh, Samantha Qian Ping.
• مؤلفون آخرون: Jimmy Pingkwan Tam @ James P Tam
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2011
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/44537
• المؤسسة: Nanyang Technological University

MVIIA is a peptide isolated from cone snail venom. It is a potent inhibitor of N-type voltage-gated calcium channels on presynaptic neurons, preventing release of neurotransmitters for pain signal transmission. Its synthetic form Ziconotide has been approved for clinical therapy but can only be admi...